FGFR2, fibroblast growth factor receptor 2, 2263

N. diseases: 731; N. variants: 141
Disease: Breast Carcinoma ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		G 0.800 GeneticVariation GWASCAT A combined analysis of genome-wide association studies in breast cancer. 20872241 2011
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		G 0.800 GeneticVariation GWASCAT A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. 17529973 2007
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		0.800 GeneticVariation GWASCAT Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study. 21263130 2011
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		G 0.800 GeneticVariation GWASCAT Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci. 27354352 2016
dbSNP: rs2981582
rs2981582
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		A 0.800 GeneticVariation GWASCAT Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci. 27354352 2016
dbSNP: rs2981582
rs2981582
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		A 0.800 GeneticVariation GWASCAT Genome-wide association study identifies novel breast cancer susceptibility loci. 17529967 2007
dbSNP: rs2981578
rs2981578
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		C 0.790 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
dbSNP: rs2981578
rs2981578
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		C 0.790 GeneticVariation GWASCAT Genome-wide association study of breast cancer in the Japanese population. 24143190 2013
dbSNP: rs2420946
rs2420946
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		A 0.770 GeneticVariation GWASCAT Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. 23544012 2013
dbSNP: rs2981579
rs2981579
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		A 0.740 GeneticVariation GWASCAT Genome-wide association study identifies five new breast cancer susceptibility loci. 20453838 2010
dbSNP: rs2981579
rs2981579
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		A 0.740 GeneticVariation GWASCAT Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. 25751625 2015
dbSNP: rs2981579
rs2981579
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		A 0.740 GeneticVariation GWASCAT Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci. 27354352 2016
dbSNP: rs2981579
rs2981579
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		T 0.740 GeneticVariation GWASCAT A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). 19330030 2009
dbSNP: rs2981579
rs2981579
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		A 0.740 GeneticVariation GWASCAT Large-scale genotyping identifies 41 new loci associated with breast cancer risk. 23535729 2013
dbSNP: rs11200014
rs11200014
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		A 0.720 GeneticVariation GWASCAT Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. 27197191 2016
dbSNP: rs3750817
rs3750817
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		T 0.720 GeneticVariation GWASCAT In addition, rs3750817 in intron 2 of the fibroblast growth factor receptor 2 gene, which was reported to be associated with breast cancer susceptibility, was significantly replicated with P(combined) of 8.47 × 10(-8) with OR=1.22. 22951594 2012
dbSNP: rs2981575
rs2981575
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		0.710 GeneticVariation GWASCAT FGFR2 rs2981575 had the strongest association with breast cancer risk (per allele HR = 1.28, 95% CI 1.18-1.39, ). 21060860 2010
dbSNP: rs35054928
rs35054928
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		GC 0.710 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
dbSNP: rs10510097
rs10510097
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		T 0.700 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
dbSNP: rs2912774
rs2912774
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		0.700 GeneticVariation GWASCAT A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age. 24493630 2014
dbSNP: rs3135718
rs3135718
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		0.700 GeneticVariation GWASCAT Strong association between the FGFR2 locus and ER status of breast cancer patients was observed (ER-positive n=6211, ER-negative n=2516; rs3135718 OR=1.34 p=5.46×10-12). 27764800 2016
dbSNP: rs3135724
rs3135724
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		0.700 GeneticVariation GWASCAT GWAS in the SIGNAL/PHARE clinical cohort restricts the association between the FGFR2 locus and estrogen receptor status to HER2-negative breast cancer patients. 27764800 2016
dbSNP: rs45631563
rs45631563
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		A 0.700 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		0.800 GeneticVariation BEFREE In this study, we evaluated the association of the SNP rs1982073 (Leu10Pro) in transforming growth factor-beta 1 (TGFB1) gene and the SNP rs1219648 in fibroblast growth factor receptor 2 (FGFR2) gene with the risk and aggressiveness of breast cancer among women of Han nationality in North China. 20640597 2011
dbSNP: rs1219648
rs1219648
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
CUI: C0678222
Disease:
Breast Carcinoma 		0.800 GeneticVariation BEFREE Seven SNPs were statistically significant (P ≤ 0.05) with the risk of overall breast cancer in the same direction as previously reported: rs10069690 (5p15/TERT), rs999737 (14q24/RAD51L1), rs13387042 (2q35/TNP1), rs1219648 (10q26/FGFR2), rs8170 (19p13/BABAM1), rs17817449 (16q12/FTO), and rs13329835 (16q23/DYL2). 23593120 2013